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187523-35-9

中文名稱 (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
英文名稱 (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
CAS 187523-35-9
分子式 C16H10ClF4NO2
分子量 359.7
MOL 文件 187523-35-9.mol
更新日期 2025/08/12 11:34:11
187523-35-9 結(jié)構(gòu)式 187523-35-9 結(jié)構(gòu)式

基本信息

中文別名
化合物FLINDOKALNER
英文別名
MaxiPost
FLINDOKALNER
BMS-204352 (BMS 204352
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-

物理化學性質(zhì)

沸點436.9±45.0 °C(Predicted)
密度1.50±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度Soluble to 100 mM in DMSO and to 100 mM in ethanol
酸度系數(shù)(pKa)10.43±0.40(Predicted)
形態(tài)粉末
顏色White to off-white
InChIInChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChIKeyULYONBAOIMCNEH-HNNXBMFYSA-N
SMILESN1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/05/22HY-108584Flindokalner187523-35-91 mg421元
2025/05/22HY-108584(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
Flindokalner		187523-35-910mM * 1mLin DMSO760元
2025/05/22HY-108584(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
Flindokalner		187523-35-95mg960元

常見問題列表

生物活性
Flindokalner (BMS-204352) 是鉀離子通道 (potassium channel) 調(diào)節(jié)劑。Flindokalner 是在 HEK293 細胞中表達的所有神經(jīng)元 Kv7 通道亞型的正調(diào)節(jié)劑。Flindokalner 是一種大電導鈣激活 K 通道 (BKca) 正向調(diào)節(jié)劑。Flindokalner 在 Kv7.1 通道 (Ki=3.7 μM) 處顯示負調(diào)節(jié)活性，并充當 GABAA 受體的負調(diào)節(jié)劑。Flindokalner 在體內(nèi)顯示出抗焦慮功效。
靶點

Ki: 3.7 μM (Kv7.1), 230 μM (Kv7.4), 605 μM (Kv7.5)

體外研究

Flindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with K i s of 230 and 605 μM, respectively.
Flindokalner (1-10 μM) causes inhibition of the Ca 2+ current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca 2+ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes.

體內(nèi)研究

Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect.
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile.

Animal Model: Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)
Dosage: i.p.
Administration: 3, 10, 30 mg/kg
Result: Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.
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