1854901-94-2
中文名稱(chēng)
TAK-828F
英文名稱(chēng)
TAK-828F
CAS
1854901-94-2
分子式
C28H32FN3O5
分子量
509.57
MOL 文件
1854901-94-2.mol
1854901-94-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13067 英文別名
TAK-828FCyclobutaneacetic acid, 3-[[(5R)-5-[[(7-fluoro-2,3-dihydro-1,1-dimethyl-1H-inden-5-yl)amino]carbonyl]-7,8-dihydro-2-methoxy-1,6-naphthyridin-6(5H)-yl]carbonyl]-, cis-
物理化學(xué)性質(zhì)
沸點(diǎn)738.8±60.0 °C(Predicted)
密度1.322±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.72±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
TAK-828F is a potent and selective orally available RORγt inverse agonist. TAK-828F showed Binding IC50 = 1.9 nM; Reporter gene IC50=6.1 nM; logD=3.53; LLE (reporter gene)=4.68. TAK-828F inhibited IL-17 production from mouse splenocytes and human peripheral blood mononuclear cells dose-dependently at concentrations of 0.01-10?μM without affecting the production of IFN-γ. TAK-828F may provide a novel therapeutic option to treat immune diseases by inhibiting Th17 and Th1/17 cells' differentiation and improving imbalance between Th17 and Treg cells.