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183849-43-6

中文名稱(chēng) ABAPERIDONE
英文名稱(chēng) ABAPERIDONE
CAS 183849-43-6
分子式 C25H25FN2O5
分子量 452.47
MOL 文件 183849-43-6.mol
183849-43-6 結(jié)構(gòu)式 183849-43-6 結(jié)構(gòu)式

基本信息

中文別名
阿巴哌酮
英文別名
ABAPERIDONE
4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-

物理化學(xué)性質(zhì)

沸點(diǎn)667.3±55.0 °C(Predicted)
密度1.320±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.48±0.10(Predicted)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

常見(jiàn)問(wèn)題列表

生物活性
Abaperidone 是一種有效的 5-HT2A 受體和多巴胺 D2 受體拮抗劑,IC50 分別為 6.2 和 17 nM。
靶點(diǎn)

D 2 Receptor

17 nM (IC 50 )

5-HT 2A Receptor

6.2 nM (IC 50 )

體外研究

Abaperidone possesses good affinity for dopamine D 2 receptors, together with a greater affinity for 5-HT 2 receptors with IC 50 of 17 and 6.2 nM, reaspectively.

體內(nèi)研究

The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs.

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