1821122-73-9
中文名稱
伊馬替尼雜質(zhì)72
英文名稱
Imatinib Impurity 72
CAS
1821122-73-9
分子式
C53H51N12O2
分子量
888.051
MOL 文件
1821122-73-9.mol
更新日期
2023/03/20 15:41:17
1821122-73-9 結(jié)構(gòu)式
基本信息
中文別名
伊馬替尼雜質(zhì)721-甲基-1,4-雙(4-(((4-甲基-3-((4-(吡啶基-3-基)嘧啶-2-基)氨基)苯基)氨基甲?；?芐基)哌嗪-1-基(伊馬替尼雜質(zhì))
英文別名
Imatinib HImatinib Imp.R
Imatinib Impurity 72
Imatinib EP Impurity D (Imatinib Dimer)
Piperazinium, 1-methyl-1,4-bis[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-
1-Methyl-1,4-bis(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazin-1-ium (Imatinib Impurity)
1-Methyl-1,4-bis[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-piperazinium DISCONTNUED
所屬類別
分析化學(xué)：藥典標準品和雜質(zhì)標準品物理化學(xué)性質(zhì)
溶解度DMSO (Slightly), Methanol (Slightly)
形態(tài)Solid
顏色Pale Yellow to Light Yellow
InChIKeyQBGARNIMTBRKNN-UHFFFAOYSA-O
SMILESN(C1C(=CC=C(NC(C2C=CC(C[N+]3(CCN(CC4C=CC(C(=O)NC5C=CC(C)=C(NC6=NC=CC(C7=CN=CC=C7)=N6)C=5)=CC=4)CC3)C)=CC=2)=O)C=1)C)C1=NC=CC(C2=CN=CC=C2)=N1
應(yīng)用領(lǐng)域
用途一
1-Methyl-1,4-bis[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-piperazinium is an impurity of Imatinib Mesylate (G407000), a tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.