1770778-45-4
中文名稱(chēng)
化合物 3,4,5-TRIHYDROXYCINNAMIC ACID DECYL ESTER
英文名稱(chēng)
2-Propenoic acid, 3-(3,4,5-trihydroxyphenyl)-, decyl ester, (2E)-
CAS
1770778-45-4
分子式
C19H28O5
分子量
336.42
MOL 文件
1770778-45-4.mol
1770778-45-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 3,4,5-TRIHYDROXYCINNAMIC ACID DECYL ESTER 英文別名
2-Propenoic acid, 3-(3,4,5-trihydroxyphenyl)-, decyl ester, (2E)-物理化學(xué)性質(zhì)
沸點(diǎn)514.2±50.0 °C(Predicted)
密度1.143±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 100 mg/mL (297.25 mM)
酸度系數(shù)(pKa)8.82±0.15(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
3,4,5-Trihydroxycinnamic acid decyl ester 是一種高效的脂質(zhì)吸收和積累抑制劑，具有抗肥胖作用。3,4,5-Trihydroxycinnamic acid decyl ester 是一種胰腺脂肪酶 (pancreatic lipase) 抑制劑，其 EC50 大約為 0.9 μM。靶點(diǎn)
EC50: 0.9 μM (pancreatic lipase)
體外研究
3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro.
3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC
50
value being approximately 0.9 μM.
3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation.
體內(nèi)研究
3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally.
| Animal Model: | 6 weeks old Male ddY mice |
| Dosage: | 30 mg/kg, 150 mg/kg |
| Administration: | Oral administration |
| Result: | Reduced plasma TG in a dose-dependent manner. |