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171722-81-9

中文名稱 171722-81-9
英文名稱 YM-46303
CAS 171722-81-9
分子式 C20H23ClN2O2
分子量 358.87
MOL 文件 171722-81-9.mol
171722-81-9 結(jié)構(gòu)式 171722-81-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13370
英文別名
YM-46303

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
YM-46303是一種毒蕈堿受體拮抗劑,對(duì) M1 和 M3 受體表現(xiàn)出最高的親和力,對(duì)M3受體的選擇性較M2受體高。
靶點(diǎn)

mAChR

體內(nèi)研究

YM-46303 shows approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats compared to oxybutynin. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.

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