169205-95-2

基本信息
2-甲硫基唑并[4,5-B]吡啶
2-甲硫基噁唑并[4,5-B]吡啶
2-甲基硫基惡唑并[4,5-B]吡啶
2-(甲巰基)惡唑并[4,5-B]吡啶
2-(甲基硫代)噁唑并[4,5-B]吡啶
2-甲硫基噁唑并【4,5-B】吡啶 1G
2-甲基硫基-[1,3]惡唑并[4,5-B]吡啶
2-(甲巰基)[1,3]惡唑并[4,5-B]吡啶
5Y-0215
5-b]pyridine
ZINC03884049
BUTTPARK 17\09-03
7-BroMo-3H-iMidazo[4
2-(Methylthio)oxazolo[4
7-broMo-2-Methyl-3H-iMidazo[4
2-(METHYLTHIO)OXAZOLO[4,5-B]PYRIDINE
2-Methylsulfanyl-oxazolo[5,4-b]pyridine
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表

53052-06-5

74-88-4
![2-甲硫基噁唑[4,5-B]吡啶](/CAS/GIF/169205-95-2.gif)
169205-95-2
步驟2:制備2-(甲硫基)惡唑并[4,5-b]吡啶 在室溫下,向攪拌中的惡唑并[4,5-b]吡啶-2(3H)-硫酮(3.0g,19.73mmol)的乙酸乙酯(30mL)溶液中依次加入碳酸鉀(3.81g,27.62mmol)和碘甲烷(3.08g,21.71mmol)。反應(yīng)混合物在室溫下攪拌過夜。反應(yīng)完成后,將混合物用水(100mL)稀釋,并用乙酸乙酯(2×50mL)萃取。合并有機(jī)相,用無水硫酸鈉干燥,過濾后減壓濃縮,得到2-甲硫基惡唑并[4,5-b]吡啶(3.0g,收率93.75%)。 1H NMR (CDCl3, 300 MHz): δ 8.46-8.44 (d, 1H), 7.71-7.68 (d, 1H), 7.20-7.15 (m, 1H), 2.81 (s, 3H). LCMS: m/z 167.0 [M + H]+.
參考文獻(xiàn):
[1] Patent: WO2015/104688, 2015, A1. Location in patent: Page/Page column 36
[2] Patent: US2016/340366, 2016, A1. Location in patent: Paragraph 0207; 0208
[3] Journal of Organic Chemistry, 1995, vol. 60, # 17, p. 5721 - 5725
[4] Ultrasonics Sonochemistry, 2010, vol. 17, # 5, p. 783 - 788
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 2075 - 2078