1646267-59-5
中文名稱
化合物 ACT-660602
英文名稱
Ethanone, 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[2-(trifluoromethyl)-5-pyrimidinyl]-5-thiazolyl]-1-piperazinyl]-
CAS
1646267-59-5
分子式
C20H20F6N8OS
分子量
534.48
MOL 文件
1646267-59-5.mol
1646267-59-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 ACT-660602 英文別名
ACT-660602Ethanone, 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[2-(trifluoromethyl)-5-pyrimidinyl]-5-thiazolyl]-1-piperazinyl]-
物理化學(xué)性質(zhì)
沸點611.0±65.0 °C(Predicted)
密度1.60±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.59±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
ACT-660602 is a Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases. ACT-660602 led to significantly reduced recruitment of the CXCR3+ CD8+ T cell in the bronchoalveolar lavage compartment when administered orally at a dose of 30 mg/kg.