1627709-94-7
中文名稱
LJI308
英文名稱
LJI308
CAS
1627709-94-7
分子式
C21H18F2N2O2
分子量
368.38
MOL 文件
1627709-94-7.mol
更新日期
2025/07/16 16:06:23
1627709-94-7 結(jié)構(gòu)式
基本信息
中文別名
RSK抑制劑(LJI308) 英文別名
LJI308CS-2181
LJI 308
LJI308
LJI308 >=98% (HPLC)
LJI-308
LJI 308
LJI308
2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol
Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件Inert atmosphere,Store in freezer, under -20°C
溶解度溶于二甲基亞砜
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
InChIInChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2
InChIKeyYUYJEQHNWKQNBT-UHFFFAOYSA-N
SMILESC1(O)=C(F)C=C(C2=C(C3=CC=C(N4CCOCC4)C=C3)C=CN=C2)C=C1F
安全數(shù)據(jù)
LJI308價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | HY-19713 | LJI308 | 1627709-94-7 | 1 mg | 409元 |
| 2025/05/22 | HY-19713 | LJI308 LJI308 | 1627709-94-7 | 10mM * 1mLin DMSO | 729元 |
| 2025/05/22 | HY-19713 | LJI308 LJI308 | 1627709-94-7 | 5mg | 900元 |
常見問(wèn)題列表
生物活性
LJI308 是一種有效的泛 RSK 抑制劑，對(duì) RSK1、RSK2 和 RSK3 的 IC50 分別為 6 nM、4 nM 和 13 nM。LJI308 抑制輻照、EGF 處理和 表達(dá) KRAS 突變的細(xì)胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。體外研究
LJI308 inhibits S6K1 with an IC
50
of 0.8 μM.
LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells.
LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%.
Cell Viability Assay
| Cell Line: | HTRY-LT cell lines |
| Concentration: | 1-10 μM |
| Incubation Time: | 96 hours |
| Result: | Decreased cell viability by up to 90%. |