161401-82-7
中文名稱
Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
英文名稱
Z-Vad-fmk, non-methylated
CAS
161401-82-7
分子式
C21H28FN3O7
分子量
453.46
MOL 文件
161401-82-7.mol
更新日期
2025/07/03 08:57:12
161401-82-7 結(jié)構(gòu)式
基本信息
中文別名
PAN-CASPASE抑制劑 英文別名
Z-VAD-FMK, Free AcidZ-VAD-FMK (Caspase Inhibitor VI)
Z-VAD(OH)-FMK (Caspase Inhibitor VI)
Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci)
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點758.0±60.0 °C(Predicted)
密度1.260±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
酸度系數(shù)(pKa)3.91±0.19(Predicted)
形態(tài)類白色固體
顏色White to light yellow
InChIKeyKCZVXULVWPSIGV-YEWWUXTCSA-N
SMILESC(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(O)=O)C(=O)CF
常見問題列表
生物活性
Z-VAD-FMK (Z-VAD(OH)-FMK) 是一種 pan caspase 抑制劑。Z-VAD-FMK 不抑制泛素 C 末端水解酶 L1 (UCHL1) 活性，即使?jié)舛雀哌_(dá) 440 μM。靶點
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Caspase
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體外研究
Z-VAD-FMK (40 μM) reverses the apoptotic effect exerted by total saponin of Solanum lyratum Thunb (TSSLT) in Hela cells. HeLa cells are pretreated with Z-VAD-FMK (40 μM) for 30 min and exposed to TSSLT (6 μg/mL) for 48 h.
Cell Viability Assay
| Cell Line: | HeLa cells |
| Concentration: | 40 μM |
| Incubation Time: | Prtreated for 30 minutes |
| Result: | Prevented TSSLT-induced cell death. More than 80% cell survival was observed. |