153747-97-8

基本信息
帕布昔利布雜質(zhì)6
帕布昔利布雜質(zhì)54
哌泊塞克雷布雜質(zhì)C
4-BOC-1-(5-溴-2-吡啶基)哌嗪
2-(N-BOC-哌嗪-1-基)-5-溴吡啶
4-(5-溴吡啶-2-基)哌嗪-1-甲酸叔丁酯
4-叔丁氧羰基-1-(5-溴-2-吡啶基)哌嗪
4-(5-溴-吡啶-2-基)-哌嗪-1-羧酸叔丁酯
4-(5-溴-吡啶-2-基)-哌嗪-1-羧酸叔丁基酯
Palbociclib impurity C
2-(4-BOC-piperazino)-5-bromopyridine
1-Boc-4-(5-bromo-2-pyridinyl)-piperazine
4-Boc-1-(5-bromo-2-pyridyl)piperazine 97%
5-Bromo-2-[4-(N-Boc)piperazin-1-yl]pyridine
Palbociclib Impurity C : Trifluoroacetic acid salt
t-Butyl 4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
ert-butyl4-(5-bromopyridin-2-yl)piperazine-1-carboxylate
4-(5-Bromo-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法

624-28-2

57260-71-6

153747-97-8
以2,5-二溴吡啶和N-BOC-哌嗪為原料合成4-Boc-1-(5-溴-2-吡啶基)哌嗪的一般步驟:在氬氣保護下,向裝有攪拌子的密封管中加入2,5-二溴吡啶(2g,10.7mmol)、叔丁醇鈉(1.6g,16.6mmol)、xantphos(400mg,0.7mmol)及甲苯(100mL),氬氣吹掃5分鐘。隨后,向反應(yīng)體系中加入叔丁基哌嗪-1-羧酸酯(3.4g,14.30mmol)和Pd2(dba)3(200mg,0.21mmol),于80℃下加熱反應(yīng)4小時(TLC監(jiān)測顯示原料完全消耗)。反應(yīng)完成后,將反應(yīng)混合物用EtOAc(200mL)稀釋,加入水(100mL),通過硅藻土床過濾,并用EtOAc(2×30mL)洗滌濾床。合并有機相,用鹽水(50mL)洗滌,無水Na2SO4干燥,減壓濃縮得粗產(chǎn)物。粗產(chǎn)物經(jīng)硅膠柱色譜(100-200目,50g,10-20% EtOAc-己烷梯度洗脫)純化,得到4-(5-溴-2-吡啶基)哌嗪-1-羧酸叔丁酯(3g,82%),為黃色固體。LCMS(ESI+):m/z:342.57 [M+H]+。
參考文獻:
[1] Organic Letters, 2003, vol. 5, # 24, p. 4611 - 4614
[2] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 123
[3] Patent: WO2007/20888, 2007, A1. Location in patent: Page/Page column 45-46
[4] Patent: US2006/293310, 2006, A1. Location in patent: Page/Page column 5
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/05/22 | H55311 | 4-Boc-1-(5-溴-2-吡啶基)哌嗪, 97% 4-Boc-1-(5-bromo-2-pyridyl)piperazine, 97% | 153747-97-8 | 1g | 280元 |
2025/05/22 | H55311 | 4-Boc-1-(5-溴-2-吡啶基)哌嗪, 97% 4-Boc-1-(5-bromo-2-pyridyl)piperazine, 97% | 153747-97-8 | 5g | 1512元 |
2025/05/22 | H55311 | 4-Boc-1-(5-溴-2-吡啶基)哌嗪, 97% 4-Boc-1-(5-bromo-2-pyridyl)piperazine, 97% | 153747-97-8 | 25g | 7560元 |