1513879-21-4
中文名稱
BQR695
英文名稱
BQR695
CAS
1513879-21-4
分子式
C19H20N4O3
分子量
352.39
MOL 文件
1513879-21-4.mol
更新日期
2025/05/06 16:15:00
1513879-21-4 結(jié)構(gòu)式
基本信息
中文別名
化合物BQR695 英文別名
BQR695NVP-BQR695
BQR695 - NVP-BQR695
BQR-695 (Synonyms: NVP-BQR695)
NVP-BQR-695
NVP-BQR 695
NVP-BQR695
Acetamide, 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl-
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)607.1±55.0 °C(Predicted)
密度1.250±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO:60.0(Max Conc. mg/mL);170.27(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.51(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.51(Max Conc. mM)
酸度系數(shù)(pKa)15.14±0.46(Predicted)
形態(tài)固體
顏色White to off-white
BQR695價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-18748 | BQR695 BQR-695 | 1513879-21-4 | 5mg | 600元 |
| 2025/02/08 | HY-18748 | BQR695 BQR-695 | 1513879-21-4 | 10mM * 1mLin DMSO | 660元 |
| 2025/02/08 | HY-18748 | BQR695 BQR-695 | 1513879-21-4 | 10mg | 950元 |
常見(jiàn)問(wèn)題列表
生物活性
BQR695 (NVP-BQR695)是PI4KIIIβ抑制劑，對(duì)人源PI4KIIIβ的IC50值約為90 nM。靶點(diǎn)
| Target | Value |
|
PI4KIIIβ
() | ~90 nM |
體外研究
Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PH Osh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines.