1502816-23-0
中文名稱
1502816-23-0
英文名稱
MS049
CAS
1502816-23-0
分子式
C15H24N2O
分子量
248.36
MOL 文件
1502816-23-0.mol
更新日期
2024/11/15 18:20:31
1502816-23-0 結(jié)構(gòu)式
基本信息
中文別名
化合物MS049PRMT4和PRMT6雙重抑制劑(MS049)
英文別名
MS049MS049 2HCl
MS049
MS-049
MS 049
2-[4-(benzyloxy)piperidin-1-yl]ethyl}(methyl)amine
1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點352.6±37.0 °C(Predicted)
密度1.03±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: ≥ 31 mg/mL (124.82 mM)
酸度系數(shù)(pKa)10.48±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
水溶解性H2O: 20mg/mL, clear
1502816-23-0價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-100360 | 1502816-23-0 MS049 | 1502816-23-0 | 5mg | 660元 |
| 2025/02/08 | HY-100360 | 1502816-23-0 MS049 | 1502816-23-0 | 10mM * 1mLin DMSO | 726元 |
| 2025/02/08 | HY-100360 | 1502816-23-0 MS049 | 1502816-23-0 | 10mg | 1100元 |
常見問題列表
生物活性
MS049 是一種高效、選擇性和細胞活性的 PRMT4 和 PRMT6 雙重抑制劑，IC50 分別為 34 nM 和 43 nM。MS049 降低了 HEK293 細胞的 Med12me2a 和 H3R2me2a 水平。MS049 對 HEK293 細胞無毒，并且沒有影響其的生長。靶點
IC50: 34 nM (PRMT4), 43 nM (PRMT6)
體外研究
MS049 (0.1-10 μM; 20 hours) reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC
50
=0.97±0.05 μM).
MS049 (0.1-100 μM; 72 hours) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC
50
=1.4±0.1 μM) in HEK293 cells.
MS049 is selective for PRMT4 and PRMT6 over a broad range of epigenetic modifiers, including other PRMTs, PKMTs, DNMTs, KDMs, and methyllysine/methylarginine reader proteins, and non-epigenetic targets.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 0.1, 1, 10 μM |
| Incubation Time: | 20 hours |
| Result: | Reduced the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC 50 =0.97±0.05 μM). |
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 0.1, 1, 10, 100 μM |
| Incubation Time: | 72 hours |
| Result: | Reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC 50 =1.4±0.1 μM) in HEK293 cells. |