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149709-44-4

中文名稱 LCZ696雜質
英文名稱 Sacubitril Impurity 7
CAS 149709-44-4
分子式 C22H25NO5
分子量 383.44
MOL 文件 149709-44-4.mol
更新日期 2025/07/15 17:12:16
149709-44-4 結構式 149709-44-4 結構式

基本信息

中文別名
CU屈二酸
沙庫比曲雜質4
沙庫比曲代謝物
脫乙基沙庫巴曲
去乙基沙庫必曲
LCZ-696雜質1
沙庫必曲起始物料雜質3
沙庫必曲代謝物LBQ657
LCZ696雜質900-04
SACUBITRIL METABOLITE LBQ 657
英文別名
LBQ657
LCZ696-4
Sacubitrilat
Deethyl Sakuba
LCZ-696 Impurity 1
Diacid of Sacubitril
Sacubitrilat (LBQ-657)
LCZ696 Impurity 900-04
Sacubitril Desethyl Impurity
Sacubitril metabolite LBQ 657
所屬類別
分析化學:藥典標準品和雜質標準品

物理化學性質

沸點705.4±60.0 °C(Predicted)
密度1?+-.0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)
酸度系數(shù)(pKa)4.59±0.23(Predicted)
形態(tài)A crystalline solid
顏色White to off-white
旋光度 (Optical Rotation)[α]/D -35 to -27°, c =1 in methanol

安全數(shù)據

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
LCZ696雜質價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2025/05/22HY-17620LCZ696雜質
Sacubitrilat
149709-44-41 mg545元
2025/05/22HY-17620LCZ696雜質
Sacubitrilat
149709-44-45mg1200元
2025/05/22HY-17620LCZ696雜質
Sacubitrilat
149709-44-410mM * 1mLin DMSO1320元

常見問題列表

生物活性
Sacubitrilat (Sac, LBQ-657) 是一種 neprilysin (NEP) 的活性抑制劑。
靶點
TargetValue
NEP
()
體外研究

Sacubitrilat (LBQ657) is a single diastereomer with specific stereocenters. Sacubitrilat is bound to the active site of NEP by an intricate network of interactions that involves all functional groups of the compound giving rise to the high inhibitory potency of 5?nM.

體內研究

Pharmacokinetics of Sacubitril, Sacubitrilat (LBQ657), and valsartan following the administration of single oral doses of LCZ696 400 or 1200 mg under fasting condition are summarized. The mean plasma concentrations of Sacubitril increases rapidly with a median T max of 0.52 h for the 400 mg dose and 1.05 h for the 1200 mg dose, followed by Sacubitrilat, with the corresponding T max values of 2.07 and 3.05 h, respectively. The median T max for valsartan is 2.07 h for both the LCZ696 400 mg and 1200 mg doses. The C max of Sacubitrilat shows a dose proportional increase, while the C max of Sacubitril and Valsartan shows less than proportional increases between the doses. The arithmetic mean AUC 0-24 h and AUC last for Sacubitril and Sacubitrilat increases approximately dose proportionally, but shows less than dose proportional increase for Valsartan.

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