1480830-24-7
中文名稱
化合物 T28275
英文名稱
Carbamimidothioic acid, N-[4-(4-chlorophenyl)butyl]-, 3-(1-piperidinyl)propyl ester
CAS
1480830-24-7
分子式
C19H30ClN3S
分子量
367.98
MOL 文件
1480830-24-7.mol
1480830-24-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28275 英文別名
OUP186OUP-186
OUP 186
Carbamimidothioic acid, N-[4-(4-chlorophenyl)butyl]-, 3-(1-piperidinyl)propyl ester
物理化學(xué)性質(zhì)
沸點490.3±55.0 °C(Predicted)
密度1.15±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)9.32±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
OUP-186 is a high affinity and humarat species-selective histamine H3 receptor antagonist. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.