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1360628-91-6

中文名稱 化合物M3541
英文名稱 Benzonitrile, 4-[2,3-dihydro-7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl]-3-fluoro-
CAS 1360628-91-6
分子式 C23H17FN6O2
分子量 428.42
MOL 文件 1360628-91-6.mol
更新日期 2024/12/03 22:59:17
1360628-91-6 結(jié)構(gòu)式 1360628-91-6 結(jié)構(gòu)式

基本信息

中文別名
化合物M3541
英文別名
4-[2,3-Dihydro-7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrile
Benzonitrile, 4-[2,3-dihydro-7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl]-3-fluoro-
所屬類別
醫(yī)藥中間體:雜環(huán)化合物

物理化學(xué)性質(zhì)

沸點634.8±65.0 °C(Predicted)
密度1.41±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)5.36±0.20(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
InChIInChI=1S/C23H17FN6O2/c1-28-12-14(10-27-28)15-7-16-18(8-21(15)32-3)26-11-20-22(16)30(23(31)29(20)2)19-5-4-13(9-25)6-17(19)24/h4-8,10-12H,1-3H3
InChIKeyOOCGUVCGJIUQKC-UHFFFAOYSA-N
SMILESC(#N)C1=CC=C(N2C3C4C(N=CC=3N(C)C2=O)=CC(OC)=C(C2=CN(C)N=C2)C=4)C(F)=C1

應(yīng)用領(lǐng)域

用途一
M3541 is a potent, selective, orally active ATM inhibitor with potential chemo-/radio-sensitizing and antineoplastic activities. M-3541 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, M 3541 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair.

常見問題列表

概述
M3541 是一種強效、ATP 競爭性和選擇性 ATM 抑制劑,IC50 為 0.25 nM。M3541 對其他蛋白激酶表現(xiàn)出顯著的選擇性。M3541 抑制雙鏈斷裂 (DSB) 修復(fù)并具有抗腫瘤活性。
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