1357289-29-2
中文名稱
度魯特韋雜質6
英文名稱
Dolutegravir Impurity 6
CAS
1357289-29-2
分子式
C20H19F2N3O5
分子量
419.38
MOL 文件
1357289-29-2.mol
更新日期
2025/06/19 18:52:30
1357289-29-2 結構式
基本信息
中文別名
度魯特韋雜質6度魯特韋雜質B
杜魯特韋雜質3
多替拉韋雜質12
度魯特韋雜質42
多替拉韋RR異構體
度魯特韋非對映異構體1
DOLUTEGRAVIR雜質B
英文別名
Dolutegravir RR IsomerDolutegravir Impurity 6
Doultegravirr RR Isomer
Dolutegravir Impurity 42
(4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aR)-
所屬類別
分析化學：藥典標準品和雜質標準品物理化學性質
沸點669.0±55.0 °C(Predicted)
密度1.53±0.1 g/cm3(Predicted)
酸度系數(pKa)4.50±1.00(Predicted)
InChIKeyRHWKPHLQXYSBKR-MEBBXXQBSA-N
SMILESO1CC[C@@H](C)N2C(=O)C3=C(O)C(=O)C(C(NCC4=CC=C(F)C=C4F)=O)=CN3C[C@@]12[H]
應用領域
用途一
Dolutegravir RR Isomer is an isomer of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.