1333126-30-9
中文名稱(chēng)
4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine
英文名稱(chēng)
4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine
CAS
1333126-30-9
分子式
C23H17ClFN5O7
分子量
529.87
MOL 文件
1333126-30-9.mol
更新日期
2025/07/13 17:53:23

基本信息
中文別名
4'-疊氮基-3-苯甲?;?5-間氯苯甲?;?2-脫氧-2'-氟-Β-D-阿拉伯尿苷4'-疊氮基-3'-O-苯甲?;?5'-O-(間氯苯甲酰基)-2'-脫氧-2'-氟-Β-D-阿拉伯哌啶
英文別名
4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzyl)-2’-deoxy-2’-fluoro-β-Darabinouridine4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine
1-[4-Azido-3-O-benzoyl-5-O-(3-chlorobenzoyl)-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)uracil
所屬類(lèi)別
有機(jī)原料:雜環(huán)化合物物理化學(xué)性質(zhì)
InChIKeyZSOIOSPOWYBGRD-MOSRZVNLNA-N
SMILESC([C@]1(O[C@@H](N2C=CC(=O)NC2=O)[C@@H](F)[C@@H]1OC(C1C=CC=CC=1)=O)N=[N+]=[N-])OC(C1C=CC=C(Cl)C=1)=O |&1:1,3,12,14,r|
應(yīng)用領(lǐng)域
用途一
1-[4-Azido-3-O-benzoyl-5-O-(3-chlorobenzoyl)-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)uracil is reported to be a reactant used for the preparation of 2''-deoxy-2''-fluoro-4''-azido nucleoside analogs which exhibited extremely potent anti-HIV activity against NL4-3 (wild-type), NL4-3 (K101E), and RTMDR viral strains. Also it is used for the synthesis of 4-substituted fluoronucleoside analogs for the treatment of Hepatitis B virus infection.常見(jiàn)問(wèn)題列表
概述
4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine 是一種嘌呤核苷類(lèi)似物。嘌呤核苷類(lèi)似物具有廣泛的抗腫瘤活性,靶向惰性淋巴系統(tǒng)惡性腫瘤。這一過(guò)程中的抗癌機(jī)制依賴(lài)于抑制 DNA 合成,誘導(dǎo)細(xì)胞凋亡 (apoptosis) 等。4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine 是一種點(diǎn)擊化學(xué)試劑。它含有 Azide 基團(tuán),可以和含有 Alkyne 基團(tuán)的分子發(fā)生銅催化的疊氮-炔環(huán)加成反應(yīng)(CuAAc)。它還可以和含有 DBCO 或 BCN 基團(tuán)的分子發(fā)生環(huán)張力驅(qū)動(dòng)的炔-疊氮環(huán)加成反應(yīng) (SPAAC)。