1251906-10-1
1251906-10-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)666.3±55.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)6.12±0.60(Predicted)
應(yīng)用領(lǐng)域
用途一
AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation.