1217723-41-5
中文名稱
甲砜霉素-D3
英文名稱
2,2-dichloro-N-[(2S,3S)-1,1,2-trideuterio-1,3-dihydroxy-3-(4-methylsulfonylphenyl)propan-2-yl]acetamide
CAS
1217723-41-5
分子式
C12H12Cl2D3NO5S
分子量
359.241
MOL 文件
1217723-41-5.mol
更新日期
2025/07/14 09:27:51
1217723-41-5 結(jié)構(gòu)式
基本信息
中文別名
[2H3]-甲砜霉素[2H3]-ENT-甲砜霉素
英文別名
[2H3]-ent-Thiamphenicol2,2-dichloro-N-[(2S,3S)-1,1,2-trideuterio-1,3-dihydroxy-3-(4-methylsulfonylphenyl)propan-2-yl]acetamide
物理化學(xué)性質(zhì)
溶解度DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
形態(tài)Solid
顏色White to Off-White
InChIInChI=1/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/s3/i6D2,9D
InChIKeyOTVAEFIXJLOWRX-RLFXQZLSNA-N
SMILESC(N[C@]([2H])([C@@H](O)C1=CC=C(S(C)(=O)=O)C=C1)C([2H])([2H])O)(=O)C(Cl)Cl |&1:2,4,r|
應(yīng)用領(lǐng)域
用途一
Labelled Thiamphenicol (T344160). Thiamphenicol is an antibiotic. Thiamphenicol is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Thiamphenicol is used particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.常見問題列表
概述
甲砜霉素-D3 是氘代標記的 Thiamphenicol (HY-B0479)。 Thiamphenicol (Thiophenicol) 是 Chloramphenicol 的甲基磺?；苌?，是一種廣譜抗菌類抗生素。Thiamphenicol 通過與 50S 核糖體亞基結(jié)合而起作用，使蛋白質(zhì)合成被抑制并具有抑菌作用 (針對革蘭氏陰性，革蘭氏陽性需氧和厭氧菌)。