1197196-63-6
中文名稱
MS0124
英文名稱
MS0124
CAS
1197196-63-6
分子式
C20H29N5O3
分子量
387.48
MOL 文件
1197196-63-6.mol
更新日期
2025/07/31 10:35:40
1197196-63-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點582.6±60.0 °C(Predicted)
密度1.232±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)8.84±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
MS0124 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. MS0124 was 34-fold more selective for GLP (IC50 =_x000D_
13 ± 4 nM) over G9a (IC50 = 440 ± 63 nM). G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates