118811-07-7
118811-07-7 結(jié)構(gòu)式
基本信息
N-BOC-4-哌啶基對(duì)甲苯磺酸酯
N-BOC-4-(4-甲苯磺酰氧基)哌啶
1-叔丁氧羰基-4-(對(duì)甲苯磺酰氧基)哌啶
4-(甲苯-4-磺酰氧)哌啶-1-羧酸叔丁酯
N-BOC-4-TOXYLOXY-PIPERIDINE
1-Boc-4-(tosyloxy)piperidine
(1-BOC-piperidin-4-yl)tosylate
N-Boc-4-piperidyl p-Methylbenzenesulfonate
t-Butyl 4-(tosyloxy)piperidine-1-carboxylate
tert-butyl 4-(tosyloxy)piperidine-1-carboxylate
4-Tosyloxypiperidine-1-carboxylic Acid tert-Butyl Es
1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine
tert-Butyl 4-(p-Toluenesulfonyloxy)piperidine-1-carboxylate
物理化學(xué)性質(zhì)
制備方法
98-59-9
109384-19-2
118811-07-7
向N-Boc-4-羥基哌啶（5g，24.8mmol）的二氯甲烷（50mL）溶液中依次加入三乙胺（13.9mL，99.4mmol）和對(duì)甲苯磺酰氯（9.47g，49.7mmol）。將反應(yīng)混合物在室溫下攪拌20小時(shí)。反應(yīng)完成后，將溶液真空濃縮。將殘余物重新溶解于二氯甲烷（20mL）和水（20mL）的混合液中，用二氯甲烷（20mL）萃取有機(jī)層。隨后，有機(jī)層用1N HCl（40mL）洗滌，再用二氯甲烷（2×40mL）萃取兩次。合并有機(jī)層，用無(wú)水硫酸鎂干燥，過(guò)濾并濃縮。最后，通過(guò)硅膠柱色譜法（石油醚/乙酸乙酯，8:2）純化粗產(chǎn)物，得到4-(甲苯-4-磺酰氧)哌啶-1-羧酸叔丁酯（8.7g，定量收率），為白色結(jié)晶固體。
參考文獻(xiàn)：
[1] Patent: WO2018/50771, 2018, A1. Location in patent: Page/Page column 72
[2] Patent: WO2007/102883, 2007, A2. Location in patent: Page/Page column 36-37
[3] Patent: WO2013/170072, 2013, A2. Location in patent: Paragraph 001074
[4] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 135
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 9958 - 9972
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | XW1188110771 | 4-(甲苯-4-磺酰氧)哌啶-1-羧酸叔丁酯 | 118811-07-7 | 1G | 33元 |
| 2025/05/22 | B4516 | 1-叔丁氧羰基-4-(對(duì)甲苯磺酰氧基)哌啶 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine | 118811-07-7 | 1g | 75元 |
| 2021/01/25 | B4516 | 1-叔丁氧羰基-4-(對(duì)甲苯磺酰氧基)哌啶 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine | 118811-07-7 | 5g | 1015元 |