1187188-60-8
中文名稱
克立硼羅中間體
英文名稱
Crisaborole intermediate
CAS
1187188-60-8
分子式
C14H13BO4
分子量
256.06
MOL 文件
1187188-60-8.mol
更新日期
2025/07/21 09:57:00
1187188-60-8 結(jié)構(gòu)式
基本信息
中文別名
克立硼羅雜質(zhì)07克立硼羅雜質(zhì)37
克立硼羅雜質(zhì)59
5-(4-(羥甲基)苯氧基)苯并[C] [1,2]氧雜硼醇-1(3H)-醇
英文別名
Crisaborole Impurity 28Crisaborole Impurity 37
Crisaborole Impurity 59
5-(4-(hydroxymethyl)phenoxy)benzo[c][1,2]oxaborol-1(3H)-ol
5-(4-(Hydroxylmethyl)phenoxy)benzo[c][1,2]oxaborol-1-(3H)-ol
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品應(yīng)用領(lǐng)域
用途一
5-(4-(Hydroxyl Methyl)phenoxy)benzo[c][1,2]oxaborol-1-(3H)-ol is an impurity for Crisaborole(H947928). Crisaborole is a series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-?(4-?Cyanophenoxy)?-?2,?3-?dihydro-?1-?hydroxy-?2,?1-?benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent.