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115664-39-6

中文名稱 3-羧基地托咪定
CAS 115664-39-6
分子式 C12H12N2O2
分子量 216.24
MOL 文件 115664-39-6.mol
115664-39-6 結(jié)構(gòu)式 115664-39-6 結(jié)構(gòu)式

基本信息

中文別名
地托米定羧酸
3-羧基地托咪定
英文別名
3-Carboxy DetoMidine
Detomidine carboxylic acid
detomidine 3-carboxylic acid
3-(1H-IMidazol-5-ylMethyl)-2-Methylbenzoic Acid
3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID
Benzoic acid, 3-(1H-imidazol-5-ylmethyl)-2-methyl-

物理化學(xué)性質(zhì)

沸點(diǎn)499.6±33.0 °C(Predicted)
密度1.278±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)3.83±0.10(Predicted)

常見問題列表

生物活性
Detomidine carboxylic acid 是 Detomidine 的主要尿代謝產(chǎn)物。Detomidine 是一種合成的 α2-腎上腺素能 (α2-adrenergic) 激動(dòng)劑,也是一種動(dòng)物鎮(zhèn)痛鎮(zhèn)靜劑。Detomidine 還具有心臟和呼吸作用以及抗利尿作用。
靶點(diǎn)

α2-adrenergic

體內(nèi)研究

Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [ 3 H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [ 3 H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected.

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