1099644-42-4
1099644-42-4 結(jié)構(gòu)式
基本信息
4-([1,1'-聯(lián)苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氫喹啉-3-羧酸乙酯
CS-1731
AOB6123
SCHEMBL3239096
ITD1
ITD-1
ITD 1
ETHYL 4-{[1,1'-BIPHENYL]-4-YL}-2,7,7-TRIMETHYL-5-OXO-1,4,6,8-TETRAHYDROQUINOLINE-3-CARBOXYLATE
4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester
物理化學(xué)性質(zhì)
制備方法
141-97-9
126-81-8
3218-36-8
1099644-42-4
以對苯基苯甲醛（1 mmol）、5,5-二甲基-1,3-環(huán)己二酮（0.14 g，1 mmol）、乙酰乙酸乙酯（0.13 g，1 mmol）、乙酸銨（0.115 g，1.5 mmol）和Fe2O3（催化量）負載于羥基磷灰石（HAP，催化量）上為原料，加入三聚氰胺（0.15 g）作為助劑，在80℃下加熱反應(yīng)。反應(yīng)進程通過薄層色譜（TLC，展開劑為正己烷/乙酸乙酯，體積比10:3）進行監(jiān)測。反應(yīng)完成后，將反應(yīng)混合物冷卻至室溫，用熱乙酸乙酯洗滌，并通過磁力分離去除催化劑。將固體殘余物分離，并通過在熱乙醇中重結(jié)晶進行純化，得到目標產(chǎn)物4-([1,1'-聯(lián)苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氫喹啉-3-羧酸乙酯。
參考文獻：
[1] RSC Advances, 2014, vol. 4, # 101, p. 57662 - 57670
[2] Research on Chemical Intermediates, 2015, vol. 41, # 10, p. 7227 - 7244
[3] Applied Organometallic Chemistry, 2016, vol. 30, # 5, p. 311 - 317
[4] Journal of Coordination Chemistry, 2017, vol. 70, # 2, p. 340 - 360
[5] Synthetic Communications, 2017, vol. 47, # 12, p. 1185 - 1191
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | HY-12704 | ITD-1 | 1099644-42-4 | 1 mg | 360元 |
| 2025/05/22 | HY-12704 | ITD 1 ITD-1 | 1099644-42-4 | 5mg | 700元 |
| 2025/05/22 | HY-12704 | ITD 1 ITD-1 | 1099644-42-4 | 10mM * 1mLin DMSO | 770元 |
常見問題列表
| Target | Value |
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TGF-β
() |
ITD-1 potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. HEK293T cells are transfected with a Smad4 response element driving luciferase (SBE4-Luc) to test whether ITD-1 blocks Activin A/Nodal and/or TGFβ signaling, which utilize the same intracellular signaling cascade through Smad4. ITD-1 strongly inhibits TGFβ2 signaling with similar efficacy (92% vs. 99% respectively), but with lower potency compared to SB-431542, an ACVR1B/TGFBR1 kinase inhibitor (IC 50 = 850nM vs. 70nM respectively), and is a weak and partial inhibitor of Activin A signals. ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors .