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109683-61-6

中文名稱 烏替普利
英文名稱 Utibapril
CAS 109683-61-6
分子式 C22H31N3O5S
分子量 449.56
MOL 文件 109683-61-6.mol
109683-61-6 結(jié)構(gòu)式 109683-61-6 結(jié)構(gòu)式

基本信息

中文別名
烏替普利
英文別名
Utibapril
FPL-63547
(2S)-5-tert-Butyl-3-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-2,3-dihydro-1,3,4-thiadiazole-2β-carboxylic acid
1,3,4-Thiadiazole-2-carboxylic acid, 5-(1,1-dimethylethyl)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-2,3-dihydro-, (2S)-

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335

常見問題列表

生物活性
Utibapril 是一種 angiotensin-converting enzyme (ACE) 抑制劑,具有抗高血壓的功效。
體內(nèi)研究

Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts.

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