108351-90-2
108351-90-2 結(jié)構(gòu)式
物理化學性質(zhì)
熔點121-123 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
沸點384.4±30.0 °C(Predicted)
密度1.162±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)8.00±0.40(Predicted)
應(yīng)用領(lǐng)域
用途一
PD 118440 is a Dopamine antagonist. It has been identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests that include [3H]-haloperidol and [3H]-N-propylnorapomorphine binding, inhibition of striatal DA synthesis, inhibition of DA neuronal firing, inhibition of spontaneous locomotor activity, and reversal of reserpine-induced depression in rats.