1076088-50-0
中文名稱(chēng)
化合物 WRR-483
英文名稱(chēng)
WRR483
CAS
1076088-50-0
分子式
C29H41N7O4S
分子量
583.75
MOL 文件
1076088-50-0.mol
1076088-50-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 WRR-483 英文別名
WRR4831-Piperazinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]carbonyl]butyl]-4-methyl-
應(yīng)用領(lǐng)域
用途一
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.