107407-80-7

基本信息
吡咯并[1,2-C]嘧啶-3-甲酸乙酯
乙基吡咯并[1,2-C]嘧啶-3-羧酸酯
Ethyl pyrrolo[1,2-c]pyriMidin-3-carboxylate
ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE
ethyl pyrrolo[1,2-f]pyrimidine-3-carboxylate
Pyrrolo<1,2-c>pyrimidin-3-carbonsaeure-ethylester
3-pyrrolo[1,2-c]pyrimidinecarboxylic acid ethyl ester
Pyrrolo[1,2-c]pyrimidine-3-carboxylic acid, ethyl ester
3-[ethoxy(oxo)Methane]pyrazolo[1,2-a][1,2,4]triazin-1-yl
ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE ISO 9001:2015 REACH
物理化學(xué)性質(zhì)
制備方法

1003-29-8

2999-46-4
![吡咯并[1,2-F]嘧啶-3-甲酸乙酯](/CAS/GIF/107407-80-7.gif)
107407-80-7
以2-吡咯甲醛和異氰基乙酸乙酯為原料合成吡咯并[1,2-c]嘧啶-3-甲酸乙酯的一般步驟:向1H-吡咯-2-甲醛(9.51 g,100.0 mmol,1.0當(dāng)量)的二氯甲烷(DCM,150.0 mL)溶液中加入1,8-二氮雜二環(huán)十一碳-7-烯(DBU,15.2 g,100.0 mmol,1.0當(dāng)量),隨后加入異氰基乙酸乙酯(11.3 g,100.0 mmol,1.0當(dāng)量)。將反應(yīng)混合物加熱至回流狀態(tài),維持3小時(shí)。反應(yīng)完成后,加入10%乙酸水溶液(250 mL)淬滅反應(yīng),分離有機(jī)相。有機(jī)相依次用水(100 mL×2)洗滌,無水硫酸鎂(MgSO?)干燥,過濾并濃縮。通過柱色譜法(石油醚/乙酸乙酯=4/1,v/v)純化殘余物,得到目標(biāo)產(chǎn)物吡咯并[1,2-c]嘧啶-3-羧酸乙酯,為黃色固體(18.5 g,收率97.3%)。
參考文獻(xiàn):
[1] Patent: WO2018/35061, 2018, A1. Location in patent: Paragraph 0448
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 14, p. 4231 - 4239
[3] Patent: US2003/236264, 2003, A1. Location in patent: Page 49
[4] Tetrahedron Letters, 1996, vol. 37, # 24, p. 4263 - 4266