1074-68-6
1074-68-6 結(jié)構(gòu)式
基本信息
2-甲硫基-4-醛基嘧啶
2-甲硫基-嘧啶-4-甲醛
2-(甲基硫基)嘧啶-4-甲醛
2-(甲基硫烷基)嘧啶-4-甲醛
2-甲硫基嘧啶-4-甲醛 25G
2-(Methylthio)pyridine-4-carbaldehyde
2-(Methylthio)-4-pyrimidinecarbaldehyde
2-(Methylthio)pyrimidine-4-carbaldehyde
2-Methylthiopyrimidine-4-carboxaldehyde
2-MethylsulfanylpyriMidin-4-carbaldehyde
2-(Methylthio)-4-pyrimidinecarboxaldehyde
2-METHYLTHIO-4-PYRIMIDINE CARBOXYALDEHYDE
2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE
2-Methylthio-4-pyrimidine carboxzyaldehyde
物理化學(xué)性質(zhì)
制備方法
180869-36-7
1074-68-6
實(shí)施例4 2-(甲硫基)嘧啶-4-甲醛(4)的合成：在60℃條件下，將4-(二甲氧基甲基)-2-(甲硫基)嘧啶(3)(53.7g, 268mmol)緩慢加入至1.2N HCl水溶液(300mL, 268mmol, 1.0當(dāng)量)中，持續(xù)攪拌3小時(shí)。反應(yīng)完成后，將混合物冷卻至室溫，并通過緩慢加入固體碳酸氫鈉進(jìn)行中和。隨后，用乙醚(3×150mL)對(duì)粗產(chǎn)物進(jìn)行萃取，合并有機(jī)層后在減壓條件下濃縮，得到目標(biāo)產(chǎn)物2-(甲硫基)嘧啶-4-甲醛(4)，為黃色固體(14.2g, 產(chǎn)率34%)。LC-MS m/z 155(M+1)。參考文獻(xiàn)：WO 2006/009734 A1, 第67頁(yè)。
參考文獻(xiàn)：
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 3, p. 1067 - 1088
[2] Patent: WO2016/7966, 2016, A2. Location in patent: Paragraph 0024
[3] Journal of Medicinal Chemistry, 2018,
[4] Patent: US2011/152235, 2011, A1. Location in patent: Page/Page column 67
[5] Patent: WO2011/103289, 2011, A2. Location in patent: Page/Page column 73; 74