| Identification | Back Directory | [Name]
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)- | [CAS]
99759-48-5 | [Synonyms]
6-benzoylheteratisine
O-benzoylheteratisine
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth yl-, (1alpha,6beta)-
Inhibitor,6Benzoylheteratisine,Sodium Channel,inhibit,6-Benzoylheteratisine,Na+ channels,Na channels,6 Benzoylheteratisine
8H-13,3,6a-Ethanylylidene-7,10-methanooxepino[3,4-i]-1-benzazocin-8-one, 14-(benzoyloxy)-1-ethyltetradecahydro-12a-hydroxy-6-methoxy-3-methyl-, (3R,6S,6aS,7R,7aS,10S,12aS,13R,13aR,14S,15R)- | [Molecular Formula]
C29H37NO6 | [MDL Number]
MFCD01937939 | [MOL File]
99759-48-5.mol | [Molecular Weight]
495.62 |
| Chemical Properties | Back Directory | [Melting point ]
212-214 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
645.9±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
13.38±0.70(Predicted) |
| Hazard Information | Back Directory | [Hazard]
A poison. | [Uses]
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na+]i, [Ca2+]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge[1][2]. | [References]
[1] Gutser UT, et al. The alkaloid 6-benzoylheteratisine inhibits voltage-gated Na+ channels in rat brain synaptosomes. Neuropharmacology. 1998 Sep;37(9):1139-46. DOI:10.1016/s0028-3908(98)00114-2
[2] Ameri A. Effects of the alkaloids 6-benzoylheteratisine and heteratisine on neuronal activity in rat hippocampal slices. Neuropharmacology. 1997 Aug;36(8):1039-46. DOI:10.1016/s0028-3908(97)00095-6 |
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