| Identification | Back Directory | [Name]
(R)-Flecainide | [CAS]
99495-90-6 | [Synonyms]
(R)-Flecainide
(R)-(-)-Flecainide
N-[(R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
N-[(2R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
N-[[(2R)-piperidin-2-yl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Benzamide, N-[(2R)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-
Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, (R)- | [Molecular Formula]
C17H20F6N2O3 | [MDL Number]
MFCD00869713 | [MOL File]
99495-90-6.mol | [Molecular Weight]
414.34 |
| Chemical Properties | Back Directory | [Boiling point ]
434.9±45.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
14.15±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
R-(–)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide . R-(–)-Flecainide prevents chloroform-induced ventricular fibrillation in mice (ED50 = 14.5 mg/kg). It also prevents ouabain-induced ectopic ventricular tachycardia in anesthetized dogs. | [Uses]
R-Enantiomer of Flecainide. Antiarrhythmic (class IC) | [Uses]
R-Enantiomer of Flecainide. Antiarrhythmic (class IC). | [in vivo]
R-(–)-Flecainide inhibits chloroform-induced fibrillation (9-20 mg/kg, po, single dose) in mice model with an ED50 of 14.5 mg/kg, and inhibits ouabain induced arrhythmias (1-3 mg/kg, ) in mongrel dog model, without toxicity[1]. | Animal Model: | Chloroform-induced ventricular fibrillation in mice[1] | | Dosage: | 9-20 mg/kg | | Administration: | po, single dose | | Result: | Prevented fibrillation. |
| Animal Model: | Ouabain induced ventricular tachycardia in mongrel dog[1] | | Dosage: | 1-3 mg/kg | | Administration: | iv, single dose | | Result: | Inhibited arrhythmias. |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|