| Identification | Back Directory | [Name]
7-BROMOQUINOLIN-2(1H)-ONE | [CAS]
99465-10-8 | [Synonyms]
7-broMoquinolin-2-ol
7-BroMo-1H-quinolin-2-one
7-BROMOQUINOLIN-2(1H)-ONE
7-Bromo-2(1H)-quinolinone
7-Bromo-2-hydroxyquinoline
2(1H)-Quinolinone, 7-broMo-
7-broMo-1,2-dihydroquinolin-2-one | [Molecular Formula]
C9H6BrNO | [MDL Number]
MFCD09743441 | [MOL File]
99465-10-8.mol | [Molecular Weight]
224.05 |
| Chemical Properties | Back Directory | [Melting point ]
270-272℃ | [Boiling point ]
375.4±42.0 °C(Predicted) | [density ]
1.620 | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
10.91±0.70(Predicted) | [Appearance]
Off-white to light brown Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 7-bromo-2-chloroquinolin-2(1H)-one from 7-bromo-2-chloroquinoline was as follows: 7-bromo-2-chloroquinoline (5.0 g, 20.6 mmol) was dissolved in a mixed solvent of 5 M aqueous hydrochloric acid (133 mL) and 1,4-dioxane (14 mL) with stirring and heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, the precipitate precipitated was collected by filtration and washed with deionized water to afford 7-bromoquinolin-2(1H)-one as a colorless solid (4.3 g, 93% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.80 (s, 1H), 7.91 (d, J=8.0 Hz, 1H), 7.63 (d, J=8.0 Hz, 1H), 7.48 (d, J=8.0 Hz, 1H), 7.34 (dd, J=8.0, 4.0 Hz, 1H), 6.53 (d, J= 4.0 Hz, 1H). | [References]
[1] Patent: US2015/210655, 2015, A1. Location in patent: Paragraph 0291
[2] Patent: US9522894, 2016, B2. Location in patent: Page/Page column 34
[3] Patent: WO2008/71961, 2008, A1. Location in patent: Page/Page column 103-104
[4] Patent: WO2006/134378, 2006, A1. Location in patent: Page/Page column 61-62 |
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