Identification | Back Directory | [Name]
HUMAN IL-1ALPHA | [CAS]
97599-22-9 | [Synonyms]
HUMAN EP HUMAN LAF HUMAN LEM HUMAN MCF HIL-1ALPHA HUMAN IL-1A HUMAN IL-1ALPHA REC IL-1A (HUMAN) IL-1 ALPHA, HUMAN REC IL-1ALPHA (HUMAN) HUMAN HEMATOPOIETIN-1 RECOMBINANT HUMAN IL-1A Endogenous Pyrogen (EP) HUMAN ENDOGENOUS PYROGEN HUMAN INTERLEUKIN-1 ALPHA INTERLEUKIN-1ALPHA, HUMAN REC INTERLEUKIN-1A (HUMAN) HUMAN MONONUCLEAR CELL FACTOR REC INTERLEUKIN-1ALPHA (HUMAN) Lymphocyte-activating factor (LAF) HUMAN LYMPHOCYTE-ACTIVATING FACTOR HUMAN LEUKOCYTE ENDOGENOUS MEDIATOR INTERLEUKIN-1ALPHA, HUMAN, RECOMBINANT, E COLI INTERLEUKIN-1ALPHA (IL-1ALPHA), HUMAN, RECOMBINANT | [MDL Number]
MFCD00131398 |
Hazard Information | Back Directory | [Biological Activity]
IL-1α (interleukin) and IL-1β bind with IL-1 receptor and function as proinflammatory cytokineswhereas IL-1Rα competes to bind with IL-1R but is not proinflammatory. IL-1α can function as an intracrine molecule or as a transcription factor. IL-1 plays a major role in ischemic brain damageas the inactivation of both IL-1α and IL-1β lead to significant suppression in brain injury. Howeverinactivation of only IL-1α does not have much influence on overall damage due to some compensatory modifications in the IL-1 system. A hospital-based case-control study showed th at rs3783553 variant in this gene is linked with reduced risk of breast cancer. Tumor cell production of IL-1α helps their transmigration across the endotheliumand the expression of IL-1α is linked with distant metastasis in patients with head and neck squamous cell carcinoma. |
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Company Name: |
Merck KGaA
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Tel: |
21-20338288 |
Website: |
www.sigmaaldrich.cn |
Company Name: |
Antibodies com
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Tel: |
65-6980-8108 65698081 |
Website: |
www.antibodies.com |
Company Name: |
Fedprotein
|
Tel: |
13041401126 |
Website: |
www.fedprotein.com |
Company Name: |
Biorbyt Ltd.
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Tel: |
+44 (0)1223 859 353 |
Website: |
http://www.biorbyt.com |
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