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ChemicalBook--->CAS DataBase List--->959687-65-1

959687-65-1

959687-65-1 Structure

959687-65-1 Structure
IdentificationBack Directory
[Name]

2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, (5R)-
[CAS]

959687-65-1
[Synonyms]

(R)-Pioglitazone
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, (5R)-
[Molecular Formula]

C19H20N2O3S
[MOL File]

959687-65-1.mol
[Molecular Weight]

356.44
Chemical PropertiesBack Directory
[Boiling point ]

575.4±45.0 °C(Predicted)
[density ]

1.260±0.06 g/cm3(Predicted)
[pka]

6.35±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

(R)-Pioglitazone ((+)-pioglitazone) is the R enantiomer of Pioglitazone (HY-13956). (R)-Pioglitazone is an orally active and selective peroxisome proliferator-activated receptor (PPARγ) agonist with high affinity binding to the PPARγ ligand-binding domain. (R)-Pioglitazone can be used for the research of Alzheimer's disease[1].
[References]

[1] Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice. J Pharmacol Exp Ther. 2004 Jun;309(3):970-7. DOI:10.1124/jpet.103.064659
[2] Chang KL, et al. Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease. Sci Rep. 2015 Mar 11;5:9000. DOI:10.1038/srep09000
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