| Identification | Back Directory | [Name]
Methyl 2-fluoro-3-methoxybenzoate | [CAS]
958991-48-5 | [Synonyms]
Methyl 2-fluoro-3-methoxybenzoate
methyl 2-fluoro-3-(methyloxy)benzoate
Benzoic acid, 2-fluoro-3-methoxy-, methyl ester
methyl 2-fluoro-3-(methyloxy)benzoate
methyl 2-fluoro-3-(methyloxy)benzoate
Methyl 2-fluoro-3-(methyloxy)benzoate | [Molecular Formula]
C9H9FO3 | [MDL Number]
MFCD14698048 | [MOL File]
958991-48-5.mol | [Molecular Weight]
184.16 |
| Chemical Properties | Back Directory | [Boiling point ]
260.5±25.0 °C(Predicted) | [density ]
1.184±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
To a suspension of 2-fluoro-3-methoxybenzoic acid (2.0 g, 11.8 mmol) in dichloromethane (20 mL) and methanol (2 mL) was added slowly and dropwise trimethylmethylsilyl diazomethane (2M ethyl ether solution, 12.3 mmol, 6.2 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and then the solvent was removed by distillation under reduced pressure. The residue was diluted with ethyl acetate, adsorbed on silica gel and purified by silica gel column chromatography in two batches to give 2.0 g (92% yield) of methyl 2-fluoro-3-methoxybenzoate. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 7.48-7.44 (m, 1H), 7.15-7.09 (m, 2H), 3.93 (s, 3H), 3.91 (s, 3H). | [References]
[1] Patent: WO2009/32667, 2009, A1. Location in patent: Page/Page column 166-167 |
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