| Identification | Back Directory | [Name]
Gypenoside L | [CAS]
94987-09-4 | [Synonyms]
Gypenoside L
β-D-Glucopyranoside, (2α,3β,12β)-2,12,20-trihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-
MAPK,Extracellular signal regulated kinases,NF-κB,Nuclear factor-κB,saponin,anti-tumor,Nuclear factor-kappaB,inhibit,ERK,anti-inflammatory,Gypenoside L,Inhibitor,p38 MAPK,cytokines,p38 | [Molecular Formula]
C42H72O14 | [MOL File]
94987-09-4.mol | [Molecular Weight]
801.02 |
| Chemical Properties | Back Directory | [Boiling point ]
912.3±65.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [form ]
Solid | [pka]
12.85±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities[1][2]. | [storage]
-20°C, protect from light | [References]
[1] Ma J, et, al. Gypenoside L Inhibits Proliferation of Liver and Esophageal Cancer Cells by Inducing Senescence. Molecules. 2019 Mar 18;24(6):1054. DOI:10.3390/molecules24061054
[2] Shen CY, et, al. Comparison of the Effects and Inhibitory Pathways of the Constituents from Gynostemma pentaphyllum against LPS-Induced Inflammatory Response. J Agric Food Chem. 2018 Oct 31;66(43):11337-11346. DOI:10.1021/acs.jafc.8b03903 |
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