| Identification | Back Directory | [Name]
GTP-GAMMA-S TETRALITHIUM SALT | [CAS]
94825-44-2 | [Synonyms]
gtp-γ-s-li4
GTP-GAMMA-S 4LI
GTP-GAMMA-S-LI4
GTPγS tetralithium salt
GTP-GAMMA-S TETRALITHIUM
GTP-GAMMA-S TETRALITHIUM SALT
Guanosine 5′-[γ-thio]triphosphate
GUANOSINE-5'-O-(3-THIOTRIPHOSPHATE) TETRALITHIUM
Guanosine 5'-[γ-thio]triphosphate (lithium salt)
guanosine 5'-[γ-thio]triphosphate tetralithium salt
GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE) TETRALITHIUM SALT
GUANOSINE-5'-O-(3-THIOTRIPHOSPHORIC ACID), TETRALITHIUM
GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE TETRALITHIUM SALT
Guanosine 5'-O-(3-Thiodiphosphate) Tetralithium Salt
Guanosine 5'-(γ-thiotriphosphoric acid)tetralithium salt
Guanosine-5''-O-(3-thiotriphosphoric acid) tetralithium salt
Guanosine-5'-(γ-thiotriphosphoric acid α,β,γ,γ-tetrakislithium) salt
GTP-γ-S-Li4, Guanosine 5μ-O-(3-thiotriphosphate) tetralithium salt
Guanosine 5-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem
GUANOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), MONOANHYDRIDE WITH PHOSPHOROTHIOIC ACID, TETRALITHIUM
Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt
[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate | [EINECS(EC#)]
305-606-1 | [Molecular Formula]
C10H17LiN5O13P3S | [MDL Number]
MFCD00135151 | [MOL File]
94825-44-2.mol | [Molecular Weight]
547.19 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: ≥75 mg/mL Solutions are very unstable; prepare immediately prior to use. | [form ]
powder | [color ]
off-white | [Water Solubility ]
Water: 75 mg/ml | [BRN ]
8182249 |
| Hazard Information | Back Directory | [Uses]
Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
- as a component of lysis buffer
- in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
- to couple with G- protein α, to study its effect on kinase activity
| [General Description]
G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells. | [Biochem/physiol Actions]
GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro. |
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