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ChemicalBook--->CAS DataBase List--->942471-37-6

942471-37-6

942471-37-6 Structure

942471-37-6 Structure
IdentificationBack Directory
[Name]

NMS-P626
[CAS]

942471-37-6
[Synonyms]

NMS-P626
Benzamide, N-[5-[(3,5-difluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-2-[[(1R)-2-methoxy-1-methylethyl]amino]-4-(4-methyl-1-piperazinyl)-
[Molecular Formula]

C28H35F2N7O4S
[MOL File]

942471-37-6.mol
[Molecular Weight]

603.69
Chemical PropertiesBack Directory
[density ]

1.396±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka]

12.545±0.20(predicted)
Hazard InformationBack Directory
[Uses]

NMS-P626 is an inhibitor of TRKA, TRKB, and TRKC, with IC50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research[1].
[IC 50]

TrkA: 8 nM (IC50); TrkB: 3 nM (IC50); TrkC: 7 nM (IC50)
[References]

[1] Ardini E, et al. The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. Mol Oncol. 2014 Dec;8(8):1495-507. DOI:10.1016/j.molonc.2014.06.001
942471-37-6 suppliers list
Company Name: TargetMol Chemicals Inc.  
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