| Identification | Back Directory | [Name]
LY 294002 | [CAS]
934389-88-5 | [Synonyms]
LY 294002, HYDROCHLORIDE SALT
LY 294002, Hydrochloride Salt, >99%
LY-294,002 hydrochloride, ≥98% (HPLC)
LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase | [Molecular Formula]
C19H18ClNO3 | [MDL Number]
MFCD01530034 | [MOL File]
934389-88-5.mol | [Molecular Weight]
343.804 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
solid | [color ]
white to off-white | [biological source]
microbial (Staphylococcus roseus) |
| Hazard Information | Back Directory | [Uses]
LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). | [General Description]
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility. | [Biological Activity]
Specific cell permeable phosphatidylinositol 3-kinase inhibitor. | [storage]
Room temperature |
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