| Identification | Back Directory | [Name]
CNV1014802 (hydrochloride) | [CAS]
934240-31-0 | [Synonyms]
CNV1014802 HCl
GSK-1014802 HCl
Raxatrigine HCl
Raxatrigine hydrochloride
GSK-1014802 hydrochloride
CNV1014802 (hydrochloride)
Raxatrigine hydrochloride(GSK1014802)
CNV1014802(Raxatrigine) hydrochloride
Raxatrigine HCl (GSK1014802, CNV1014802)
GSK-1014802;GSK 1014802;CNV-1014802;CNV 1014802
(2S,5R)-5-[4-[(2-fluorophenyl)methoxy]phenyl]pyrrolidine-2-carboxamide
(5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-L-prolinamide HYDROCHLRIDE
(5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-L-prolinamide hydrochloride
(2S,5R)-5-(4-((2-Fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide hydrochloride
2-Pyrrolidinecarboxamide, 5-[4-[(2-fluorophenyl)methoxy]phenyl]-, hydrochloride (1:1), (2S,5R)- | [Molecular Formula]
C18H20ClFN2O2 | [MOL File]
934240-31-0.mol | [Molecular Weight]
350.815 |
| Chemical Properties | Back Directory | [Melting point ]
>206°C (dec.) | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Raxatrigine Hydrochloride is used as co-therapy for the treatment of epilepsy and related disorders. | [Synthesis]
(2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide (5.46 g, 17.37 mmol) was used as a raw material, which was dissolved in ethyl acetate (140 mL), stirred for 30 min and filtered. To the filtrate was added a dioxane solution (6.51 mL, 26.05 mmol) in 4 M HCl and the reaction was stirred at room temperature for 20 minutes, followed by cooling in an ice bath for 15 minutes. The resulting solid was collected by filtration, washed with cold ethyl acetate (2 x 20 mL) and dried under vacuum first at 35 °C overnight and then at 50 °C for 2 h to give an off-white solid product (E1, 5.87 g, 96% yield).LC-MS showed MH+ = 315 (corresponding to molecular formula C18H19FN2O2).1H NMR (d6-DMSO) data were as follows: δ 1.95-2.20 (2H, m), 2.30 (2H, m), 3.35 (1H, s), 4.30 (1H, m), 4.61 (1H, m), 5.18 (2H, s), 7.10 (2H, d, J = 9 Hz), 7.18-7.30 (2H, m), 7.40 (1H, m), 7.47 (2H, d, J = 9 Hz), 7.56 (1H, s), 7.72 (1H, s), 8.07 (1H, s), 10.60 (1H, br s). | [IC 50]
Nav1.7 | [storage]
Store at -20°C | [References]
[1] Patent: WO2016/102967, 2016, A1. Location in patent: Page/Page column 43
[2] Patent: WO2011/29762, 2011, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2007/42239, 2007, A1. Location in patent: Page/Page column 45
[4] Patent: WO2007/42239, 2007, A1. Location in patent: Page/Page column 45-46
[5] Patent: WO2007/42239, 2007, A1. Location in patent: Page/Page column 46 |
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