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ChemicalBook--->CAS DataBase List--->924898-09-9

924898-09-9

924898-09-9 Structure

924898-09-9 Structure
IdentificationBack Directory
[Name]

LY2157299
[CAS]

924898-09-9
[Synonyms]

LY2157299 (hydrate)
Galunisertib Hydrate
4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide,hydrate
[Molecular Formula]

C22H21N5O2
[MOL File]

924898-09-9.mol
[Molecular Weight]

387.44
Hazard InformationBack Directory
[Uses]

Galunisertib monohydrate is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC50 of 56 nM.
[References]

[1] Bueno L, et al. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice. Eur J Cancer. 2008 Jan;44(1):142-50. DOI:10.1016/j.ejca.2007.10.008
[2] Cong L, et al. Targeting the TGF-β receptor with kinase inhibitors for scleroderma therapy. Arch Pharm (Weinheim). 2014 Sep;347(9):609-15. DOI:10.1002/ardp.201400116
[3] Serova M, et al. Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients. Oncotarget. 2015 Aug 28;6(25):21614-27 DOI:10.18632/oncotarget.4308
[4] Herbertz S, et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des Devel Ther. 2015 Aug 10;9:4479-99. DOI:10.2147/DDDT.S86621
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