| Chemical Properties | Back Directory | [Boiling point ]
602.6±55.0 °C(Predicted) | [density ]
1.055±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 30 mg/ml | [form ]
A film | [pka]
5.00±0.19(Predicted) |
| Hazard Information | Back Directory | [Description]
Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora. It inhibits IL-1β-induced microsomal prostaglandin E2 synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 μM. It has higher antioxidant activity relative to (±)-α-tocopherol in a cell-free assay when used at a concentration of 0.15 mM. | [Uses]
Garcinoic Acid displays anti-angiogenic activity as well as anti-oxidative activity in animals. | [General Description]
Natural product derived from plant source. | [storage]
Store at -20°C | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] KHALED ALSABIL. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.[J]. Planta medica, 2016, 82 11-12: 1110-1116. DOI: 10.1055/s-0042-108739
[3] KENJI TERASHIMA Masatake N Yoshiaki Takaya. Powerful antioxidative agents based on garcinoic acid from Garcinia kola[J]. Bioorganic & Medicinal Chemistry, 2002, 10 5: Pages 1619-1625. DOI: 10.1016/s0968-0896(01)00428-x |
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Sigma-Aldrich
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Merck KGaA
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www.sigmaaldrich.cn |
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