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ChemicalBook--->CAS DataBase List--->917572-74-8

917572-74-8

917572-74-8 Structure

917572-74-8 Structure
IdentificationBack Directory
[Name]

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-
[CAS]

917572-74-8
[Synonyms]

4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-
[Molecular Formula]

C81H163N9O5
[MOL File]

917572-74-8.mol
[Molecular Weight]

1343.22
Chemical PropertiesBack Directory
[Boiling point ]

1225.6±65.0 °C(Predicted)
[density ]

0.942±0.06 g/cm3(Predicted)
[solubility ]

Chloroform: 30 mg/ml
[form ]

A crystalline solid
[pka]

15.70±0.46(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Description]

98N12-5 is an ionizable cationic lipid.1 It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.2
[Uses]

98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA-delivery to the liver.
[References]

1. Akinc, A., Goldberg, M., Qin, J., et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver Mol. Ther. 17(5),872-879(2009).
2. Frank-Kamenetsky, M., Grefhorst, A., Anderson, N.N., et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Proc. Natl. Acad. Sci. USA 105(33),11915-11920(2008).
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