| Identification | Back Directory | [Name]
4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- | [CAS]
917572-74-8 | [Synonyms]
4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]- | [Molecular Formula]
C81H163N9O5 | [MOL File]
917572-74-8.mol | [Molecular Weight]
1343.22 |
| Chemical Properties | Back Directory | [Boiling point ]
1225.6±65.0 °C(Predicted) | [density ]
0.942±0.06 g/cm3(Predicted) | [solubility ]
Chloroform: 30 mg/ml | [form ]
A crystalline solid | [pka]
15.70±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
98N12-5 is an ionizable cationic lipid.1 It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.2 | [Uses]
98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA-delivery to the liver. | [References]
1. Akinc, A., Goldberg, M., Qin, J., et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver Mol. Ther. 17(5),872-879(2009).
2. Frank-Kamenetsky, M., Grefhorst, A., Anderson, N.N., et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Proc. Natl. Acad. Sci. USA 105(33),11915-11920(2008). |
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