| Identification | Back Directory | [Name]
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER | [CAS]
914349-79-4 | [Synonyms]
N-Boc-2-Amino-5-bromopyrazine
2-Bromo-5-(boc-amino)pyrazine
2-Amino-5-bromopyrazine, 2-BOC
tert-Butyl (5-bromopyrazin-2-yl)
2-Amino-5-bromopyrazine, 2-BOC protected
2-Amino-5-bromopyrazine, 2-BOC protected 98%
(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
(5-BROMOPYRAZINYL)CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
CarbaMicacid,(5-broMopyrazinyl)-,1,1-diMethylethylester
tert-Butyl (5-bromopyrazin-2-yl)carbamate, 2-Bromo-5-[(tert-butoxycarbonyl)amino]-1,4-diazine | [Molecular Formula]
C9H12BrN3O2 | [MDL Number]
MFCD08275683 | [MOL File]
914349-79-4.mol | [Molecular Weight]
274.11 |
| Chemical Properties | Back Directory | [Boiling point ]
295.2±40.0 °C(Predicted) | [density ]
1.513±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
10.75±0.70(Predicted) | [InChI]
InChI=1S/C9H12BrN3O2/c1-9(2,3)15-8(14)13-7-5-11-6(10)4-12-7/h4-5H,1-3H3,(H,12,13,14) | [InChIKey]
PNYUSBALYDXDRK-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NC1=NC=C(Br)N=C1 |
| Hazard Information | Back Directory | [Uses]
(5-BROMOPYRAZIN-2-YL) CARBAMIC ACID TERT-BUTYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
At 0 ??, to 5-bromopyrazine-2-amine (5736.8mg, 32.97mmol) in CH2Cl2 (80mL) solution was added 4-DMAP (403.2mg, 3.30mmol); then at 0 ?? drop two A solution of di-tert-butyl carbonate (11.4ml, 3.30mmol) in CH2Cl2; the mixture was stirred at room temperature; after the completion of the reaction was monitored by TLC, the solution was washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo; the crude product was chromatographed on a silica gel column Method, purified with ethyl acetate/petroleum ether (1/2) to obtain a white solid product (7250.4 mg, yield 80.2%). |
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T&W GROUP
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www.novochemy.com |
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