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ChemicalBook--->CAS DataBase List--->914295-16-2

914295-16-2

914295-16-2 Structure

914295-16-2 Structure
IdentificationBack Directory
[Name]

FostaMatinib DisodiuM Hexahydrate
[CAS]

914295-16-2
[Synonyms]

914295-16-2
Fostamatinib Na
R788 (disodiuM hexahydrate)
FostaMatinib DisodiuM Hexahydrate
Fostamatinib disodium salt hexahydrate
R788 Disodium Hexahydrate (Fostamatinib Disodium Hexahydrate)
Fostamatinib Disodium Hexahydrate DISCONTINUED. Please see R070115.
6-[[5-Fluoro-2-[(3,4,5-triMethoxyphenyl)aMino]-4-pyriMidinyl]aMino]-2,2-diMethyl-4-[(phosphonooxy)Methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one SodiuM Salt Hydrate
6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one disodium salt hexahydrate
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, disodium salt, hexahydrate
[Molecular Formula]

C23H24FN6Na2O9P
[MOL File]

914295-16-2.mol
[Molecular Weight]

624.423
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to gray
[CAS DataBase Reference]

914295-16-2
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H332-H335
[Precautionary statements ]

P280-P305+P351+P338-P310
Hazard InformationBack Directory
[Uses]

A spleen tyrosine kinase inhibitor prodrug for the treatment of inflammatory diseases.
[in vivo]

Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406[1].

[storage]

Store at -20°C
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