| Identification | Back Directory | [Name]
NSC49652 | [CAS]
908563-68-8 | [Synonyms]
NSC49652
(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone
(2E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one
2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(3-pyridinyl)-, (2E)- | [Molecular Formula]
C14H11NO2 | [MDL Number]
MFCD00499170 | [MOL File]
908563-68-8.mol | [Molecular Weight]
225.24 |
| Chemical Properties | Back Directory | [Boiling point ]
414.3±45.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 20.83 mg/mL (92.48 mM) | [form ]
Solid | [pka]
7.68±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone is used in the synthesis of 2,4,6-Trisubstituted Pyrimidines. | [Biological Activity]
NSC49652 is a orally activepotent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) th at targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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