| Identification | Back Directory | [Name]
THERMOLYSIN | [CAS]
9073-78-3 | [Synonyms]
Thermoase
Protex 14L
Protealysin
THERMOLYSIN
EC 3.4.24.2
EC 3.4.24.4
EC 3.4.24.27
EC 3.4.24.37
PeptiCLEC-TR
Protin AC 10F
Thermoase Y 10
Thermoase C160
PROTEASE TYPE X
Type-X protease
Thermoase PS 160
Thermoase PC 10F
Thermolysin PC 1012
Thermolysin-like protease
THERMOPHILIC-BACTERIAL PROTEASE
thermolysin F. bac. thermoproteolyticus
Thermolysin Bacillus thermoproteolyticus rokko
Thermolysin from Geobacillus stearothermophilus
Bacillus thermoproteolyticus neutral proteinase
Native Bacillus thermoproteolyticus Thermolysin
Proteinase, Bacillus thermoproteolyticus neutral
protease from bacillus thermoproteolyticus rokko
thermolysin from bacillus*thermoproteolyticus rok
Native Geobacillus stearothermophilus Thermolysin
Thermolysin from BaClllus thermoproteolyticus rokko
THERMOLYSIN FROM BACILLUS*THERMOPROTEOLY TICUS ROKKO
THERMOLYSIN F. BAC. THERMOPROTEOLYTICUS, LYO.,STAB.,~40 U/MG
Thermolysin from Bacillus thermoproteolyticus rokko,Protease from Bacillus thermoproteolyticus rokko, Thermophilic-bacterial protease | [EINECS(EC#)]
232-973-4 | [Molecular Formula]
NULL | [MDL Number]
MFCD00165549 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [color ]
tan or off-white | [biological source]
Geobacillus stearothermophilus | [Specific Activity]
30-350units/mg protein (E1%/280) |
| Hazard Information | Back Directory | [Uses]
In studies of protein sequences. | [Uses]
Thermolysin has been shown to have a prosequeence that acts as an intramolecular chaperone in vivo. It has also been used in a study to investigate the effects of sodium chloride on thermal stability and catalytic activity. | [General Description]
Thermolysin is a protease that has specificity different from other proteases available for sequence investigations. | [in vivo]
Thermolysin (50 mg/kg, p.o., once) lowers systolic blood pressure in SHR rats[4].
Thermolysin is not acutely toxic with an oral LD50 of more than 18000 mg/kg in rats and more than 24000 mg/kg in mice (Acute toxicity studies)[5].
| Animal Model: | Spontaneously hypertensive rats (SHR) rats[4] | | Dosage: | 50 mg/kg | | Administration: | Oral administration (p.o.), once | | Result: | Lowered systolic blood pressure in SHR rats, with maximal reduction by 22 mm in systolic blood pressure being observed 6 h after administration. |
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