| Identification | Back Directory | [Name]
PHOSPHORYLASE B | [CAS]
9012-69-5 | [Synonyms]
EC 2.4.1.1
PHOSPHORYLASE B
α-glucan phosphorylase
Dephosphophosphorylase
GLYCOGEN PHOSPHORYLASE
PHOSPHORYLASE B, RABBIT
Glycogen phosphorylase b
ALPHA-GLUCAN PHOSPHORYLASE
Native Rabbit Phosphorylase b
Phosphorylase B From Rabbit Muscl
PHOSPHORYLASE B CROSS-LINKED RABBIT
PHOSPHORYLASE B, RABBIT SKELETAL MUSCLE
Phosphorylase B ex. Rabbit Muscle, 50U/mg
PHOSPHORYLASE B FROM RABBIT MUSCLE*FOR S DS GEL
PHOSPHORYLASE B FROM RABBIT MUSCLE, LYOP H., ~10 U/MG
1,4-ALPHA-D-GLUCAN: ORTHOPHOSPHATE ALPHA-D-GLUCOSYLTRANSFERASE
α-Glucan Phosphorylase, Glycogen Phosphorylase, 1,4-α-D-Glucan:orthophosphate α-D-glucosyltransferase | [EINECS(EC#)]
232-737-0 | [MDL Number]
MFCD00131905 |
| Hazard Information | Back Directory | [Uses]
Phosphorylase b from rabbit muscle has been used as a molecular weight marker in 12% polyacrylamide gel for keratinase, and stress-70 protein. | [Uses]
Phosphorylase b is used to study the conversion mechanism of inactive phosphorylase b to active phosphorylase in muscle. Phosphorylase b is used to study which factors influence the conversion of phosphorylase b to phosphorylase a such as temperature, AMP, fluoride and detergents. It is used to study phosphorylase b deficiency mutations. | [General Description]
Phosphorylase b is a dimer, usually exists in inactive form in the skeletal muscles. Equilibrium exists between an active relaxed (R) state and a less active tense (T). Phosphorylase b favors the T state. The enzyme possesses three domains, the N-terminal domain, glycogen-binding domain and the C-terminal domain. | [Biochem/physiol Actions]
Phosphorylase b is a non-active form and is present in resting muscle. Phosphorylase b kinase activity increases significantly when the Mg2+:ATP ratio exceeds 1. The breakdown of ATP during muscle contraction is thought to trigger in vivo conversion of phosphorylase b into a. Phosphorylase b is activated by inosine monophosphate. |
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