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ChemicalBook--->CAS DataBase List--->900308-84-1

900308-84-1

900308-84-1 Structure

900308-84-1 Structure
IdentificationBack Directory
[Name]

SEC inhibitor KL-1
[CAS]

900308-84-1
[Synonyms]

KL1;KL-1;KL 1
SEC inhibitor KL-1
[Molecular Formula]

C18H16ClNO4
[MDL Number]

MFCD32201057
[MOL File]

900308-84-1.mol
[Molecular Weight]

345.78
Chemical PropertiesBack Directory
[Boiling point ]

552.4±50.0 °C(Predicted)
[density ]

1.339±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 41.67 mg/mL (120.51 mM)
[form ]

Solid
[pka]

8.09±0.50(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H302-H319-H335
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard InformationBack Directory
[Uses]

SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM[1][2].
[in vivo]

SEC inhibitor KL-1 (50 mg/kg, administered intraperitoneally, once daily, 15 days) disrupts SEC, which can slow down tumor progression and improve survival rates in MDA231-LM2 tumor mice[2].

Animal Model:Mouse MDA231-LM2 tumor model[2]
Dosage:50 mg/kg, once a day, 15 days
Administration:Intraperitoneal injection (i.p.)
Result:Reduced tumor volume and significantly extended survival time of recipient mice.
[References]

[1] Hiroaki Katagi, et al. Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. Neuro Oncol. 2021 Aug 2;23(8):1348-1359. DOI:10.1093/neuonc/noab009
[2] Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779. DOI:10.1016/j.cell.2018.09.027
Spectrum DetailBack Directory
[Spectrum Detail]

SEC inhibitor KL-1(900308-84-1)1HNMR
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